Cyclization of free radicals at the C-7 position of ethyl indole-2-carboxylate derivatives: an entry to a new class of Duocarmycin Analogues.

نویسندگان

  • Naim H Al-Said
  • Khaled Q Shawakfeh
  • Wasim N Abdullah
چکیده

Aryl free-radicals generated at the C-7 position of ethyl indole-2-carboxylates bearing N-allyl and propargylic groups triggered intramolecular cyclizations to furnish a new class of Duocarmycin analogues, formal ethyl pyrrolo[3,2,1-ij]quinoline-2- carboxylate derivatives, through the less favorable 6-endo-trig cyclization mode.

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عنوان ژورنال:
  • Molecules

دوره 10 12  شماره 

صفحات  -

تاریخ انتشار 2005